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Malic acid, an organic dicarboxylic acid with two stereoisomeric forms, plays an important biochemical role in both the Calvin cycle and the citric acid cycle. It is used as a food additive and preservative, a therapeutic agent, and a dietary supplement.
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Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that occurs naturally in fruits like apples and pears with oral activities Malic acid plays a role in many sour or tangy foods Malic acid is an intermediate in the citric acid cycle[1][2]
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Malate dehydrogenase (MDH), also known as EC 1.1.1.37, catalyzes the reversible interconversion of oxaloacetate and malate, playing a crucial role in metabolic pathways involving the oxidation/reduction of dinucleotide coenzymes.
Enzymatic activity: ≥10 U/mg solid
Molecular weight: approximately 35,000
Michaelis constant: 1.5x10⁻⁶ M (NADH, 37°C); 1.9x10⁻⁶ M (oxaloacetate, 37°C)
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The racemate of L-malic acid; reduces IFN-γ and TNF-α-induced CCL2 and ICAM expression in HaCaT human keratinocytes at 1 mM; inhibits epidermis and dermis thickening, as well as mast cell and eosinophil dermal infiltration in a mouse model of DNBC-induced atopic dermatitis at 10 mM
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